Ginger is a true superfood, it is abundant with health benefits and in food dishes around the world, ginger is one of the most thoroughly scientifically backed plants. Gingerol is an organic substance found in ginger, it is an anti-inflammatory, antibiotic, antimicrobial, and antioxidant.
As a tea, ginger is used to treat indigestion, nausea, flu, colds, sore throats, and gut inflammation. It has been found to boost liver health, warm up the bodily system, and even supress cancer cells. Pregnant women may find relief when regularly drinking ginger tea because it helps reduce the nausea associated with morning sickness.
Ginger can be applied topically to reduce the pain from osteoarthritis when combined with mastic, cinnamon, and sesame oil.
Incorporating fresh or powdered ginger into the diet has many uses. According to studies, ginger may protect the brain against Alzheimer’s and improve brain function if consumed regularly. New research and findings have shown that ginger may significantly lower blood sugar levels, as well as reduce the risk of heart disease. It is helpful in lowering LDL cholesterol, similarly to modern day medication and without life diminishing side effects.
Please use moderation and care when using herbs and read our disclaimer
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Ginger: Health Benefits & Side-Effects. (n.d.). WebMD. Retrieved August 16, 2020, from https://www.webmd.com/vitamins-and-supplements/ginger-uses-and-risks
Wang, S., Zhang, C., Yang, G., & Yang, Y. (2014). Biological properties of 6-gingerol: a brief review. Natural Product Communications, 9(7), 1027–1030.
Chaiyakunapruk, N., Kitikannakorn, N., Nathisuwan, S., Leeprakobboon, K., & Leelasettagool, C. (2006). The efficacy of ginger for the prevention of postoperative nausea and vomiting: a meta-analysis. American Journal of Obstetrics and Gynecology, 194(1), 95–99. https://doi.org/10.1016/j.ajog.2005.06.046
Viljoen, E., Visser, J., Koen, N., & Musekiwa, A. (2014). A systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting. Nutrition Journal, 13, 20. https://doi.org/10.1186/1475-2891-13-20
Black, C. D., Herring, M. P., Hurley, D. J., & O’Connor, P. J. (2010). Ginger (Zingiber officinale) reduces muscle pain caused by eccentric exercise. The Journal of Pain: Official Journal of the American Pain Society, 11(9), 894–903. https://doi.org/10.1016/j.jpain.2009.12.013
Black, C. D., & O’Connor, P. J. (2010). Acute effects of dietary ginger on muscle pain induced by eccentric exercise. Phytotherapy Research: PTR, 24(11), 1620–1626. https://doi.org/10.1002/ptr.3148
Altman, R. D., & Marcussen, K. C. (2001). Effects of a ginger extract on knee pain in patients with osteoarthritis. Arthritis and Rheumatism, 44(11), 2531–2538. https://doi.org/10.1002/1529-0131(200111)44:11<2531::aid-art433>3.0.co;2-j
Chang, J. S., Wang, K. C., Yeh, C. F., Shieh, D. E., & Chiang, L. C. (2013). Fresh ginger (Zingiber officinale) has anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines. Journal of Ethnopharmacology, 145(1), 146–151. https://doi.org/10.1016/j.jep.2012.10.043
Park, M., Bae, J., & Lee, D.-S. (2008). Antibacterial activity of [10]-gingerol and [12]-gingerol isolated from ginger rhizome against periodontal bacteria. Phytotherapy Research: PTR, 22(11), 1446–1449. https://doi.org/10.1002/ptr.2473
Azam, F., Amer, A. M., Abulifa, A. R., & Elzwawi, M. M. (2014). Ginger components as new leads for the design and development of novel multi-targeted anti-Alzheimer’s drugs: a computational investigation. Drug Design, Development and Therapy, 8, 2045–2059. https://doi.org/10.2147/DDDT.S67778