nutmeg

Nutmeg

Nutmeg is a powerful antioxidant, has anti-inflammatory and antibacterial properties.  It is a popular spice in cuisine around the world; however, it seems that its benefits for the body are widely underrated.  It contains cyanidins, essential oils, phenolic compounds, and other powerful antioxidants, maintaining cell health and slowing cell decay and aging.  

Studies have shown that nutmeg fights tooth decaying bacteria, inhibits the growth of E. Coli bacteria strains, and acts as a detoxifier. 

Nutmeg is used to regulate blood sugar levels and to improve heart and brain health.  It is indicated for reducing anxiety, and in helping to prevent leukaemia. It contains myristicin, a beneficial compound that could be effective against Alzheimer’s and other cognitive diseases.

Please use moderation and care when using herbs and read our disclaimer

6784680 {6784680:E9N6KGI5},{6784680:MWYI7IE5},{6784680:XHKHQT28},{6784680:NQJ5QDUC},{6784680:V7VS9GII},{6784680:RZ7RYJKS},{6784680:WTCGI6SE},{6784680:9UHHBGGQ},{6784680:I65HTAAV},{6784680:9AVJYFDJ} 1 apa 50 default 1434 https://lae.nfa.temporary.site/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22E9N6KGI5%22%2C%22library%22%3A%7B%22id%22%3A6784680%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Brandi%20Marcene%22%2C%22parsedDate%22%3A%222019-09-24%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BBrandi%20Marcene.%20%282019%2C%20September%2024%29.%2013%20Amazing%20Health%20Benefits%20of%20Nutmeg.%20%26lt%3Bi%26gt%3BNatural%20Food%20Series%26lt%3B%5C%2Fi%26gt%3B.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.naturalfoodseries.com%5C%2F13-health-benefits-nutmeg%5C%2F%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fwww.naturalfoodseries.com%5C%2F13-health-benefits-nutmeg%5C%2F%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22blogPost%22%2C%22title%22%3A%2213%20Amazing%20Health%20Benefits%20of%20Nutmeg%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22%22%2C%22lastName%22%3A%22Brandi%20Marcene%22%7D%5D%2C%22abstractNote%22%3A%22Nutmeg%20health%20benefits%20includes%20promoting%20digestion%2C%20supporting%20oral%20health%2C%20detoxifying%20the%20body%2C%20supporting%20kidney%20health%2C%20treating%20insomnia%2C%20relieving%20pain%20and%20treating%20cancer.%20Other%20benefits%20includes%20treating%20inflammation%2C%20promoting%20blood%20circulation%2C%20supporting%20immune%20system%2C%20and%20treating%20acne.%22%2C%22blogTitle%22%3A%22Natural%20Food%20Series%22%2C%22date%22%3A%222019-09-24T20%3A00%3A23%2B00%3A00%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.naturalfoodseries.com%5C%2F13-health-benefits-nutmeg%5C%2F%22%2C%22language%22%3A%22en-US%22%2C%22collections%22%3A%5B%22U8LU2X8Y%22%5D%2C%22dateModified%22%3A%222020-08-29T02%3A13%3A01Z%22%7D%7D%2C%7B%22key%22%3A%22MWYI7IE5%22%2C%22library%22%3A%7B%22id%22%3A6784680%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Stein%20et%20al.%22%2C%22parsedDate%22%3A%222001-04-15%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BStein%2C%20U.%2C%20Greyer%2C%20H.%2C%20%26amp%3B%20Hentschel%2C%20H.%20%282001%29.%20Nutmeg%20%28myristicin%29%20poisoning--report%20on%20a%20fatal%20case%20and%20a%20series%20of%20cases%20recorded%20by%20a%20poison%20information%20centre.%20%26lt%3Bi%26gt%3BForensic%20Science%20International%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B118%26lt%3B%5C%2Fi%26gt%3B%281%29%2C%2087%26%23x2013%3B90.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fs0379-0738%2800%2900369-8%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fs0379-0738%2800%2900369-8%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Nutmeg%20%28myristicin%29%20poisoning--report%20on%20a%20fatal%20case%20and%20a%20series%20of%20cases%20recorded%20by%20a%20poison%20information%20centre%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22U.%22%2C%22lastName%22%3A%22Stein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H.%22%2C%22lastName%22%3A%22Greyer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H.%22%2C%22lastName%22%3A%22Hentschel%22%7D%5D%2C%22abstractNote%22%3A%22In%20literature%2C%20cases%20of%20nutmeg%20abuse%20have%20been%20described%20repeatedly%2C%20but%20only%20one%20fatal%20case%20of%20poisoning%20was%20reported%20%5B1%5D.%20In%20the%20present%20case%2C%20myristicin%20%284%20microg%5C%2Fml%29%20was%20detected%20for%20the%20first%20time%20in%20the%20postmortal%20serum%20of%20a%2055-year-old%20woman.%20Identification%20was%20achieved%20with%20the%20aid%20of%20UV-VIS%20spectroscopy%20and%20TLC%3B%20for%20quantification%2C%20HPLC%20was%20used.%20Because%20also%20flunitrazepam%20%280.072%20microg%5C%2Fml%29%20was%20found%2C%20death%20had%20probably%20been%20due%20to%20the%20combined%20toxic%20effect%20of%20both%20substances.%20From%201996%20to%201998%2C%20in%20a%20series%20of%20cases%2C%20seven%20poisonings%20with%20nutmeg%20were%20recorded%20by%20the%20Erfurt%20Poison%20Information%20Centre.%20Even%20where%20higher%20doses%20%2820-80%20g%20of%20powder%29%20had%20been%20ingested%2C%20a%20life-threatening%20situation%20was%20never%20observed.%20In%20one%20of%20these%20cases%2C%20a%20myristicin%20blood%20level%20of%202%20microg%5C%2Fml%20was%20measured%208h%20after%20ingestion%20of%20two%20to%20three%20tablespoonful%20of%20nutmeg%20powder%20%28approx.%2014-21%20g%2C%20or%20280-420%20mg%5C%2Fkg%29.%22%2C%22date%22%3A%22Apr%2015%2C%202001%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fs0379-0738%2800%2900369-8%22%2C%22ISSN%22%3A%220379-0738%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22U8LU2X8Y%22%5D%2C%22dateModified%22%3A%222020-08-29T02%3A12%3A08Z%22%7D%7D%2C%7B%22key%22%3A%22XHKHQT28%22%2C%22library%22%3A%7B%22id%22%3A6784680%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Pashapoor%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BPashapoor%2C%20A.%2C%20Mashhadyrafie%2C%20S.%2C%20%26amp%3B%20Mortazavi%2C%20P.%20%282020%29.%20Ameliorative%20effect%20of%20Myristica%20fragrans%20%28nutmeg%29%20extract%20on%20oxidative%20status%20and%20histology%20of%20pancreas%20in%20alloxan%20induced%20diabetic%20rats.%20%26lt%3Bi%26gt%3BFolia%20Morphologica%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B79%26lt%3B%5C%2Fi%26gt%3B%281%29%2C%20113%26%23x2013%3B119.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5603%5C%2FFM.a2019.0052%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5603%5C%2FFM.a2019.0052%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Ameliorative%20effect%20of%20Myristica%20fragrans%20%28nutmeg%29%20extract%20on%20oxidative%20status%20and%20histology%20of%20pancreas%20in%20alloxan%20induced%20diabetic%20rats%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Pashapoor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Mashhadyrafie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Mortazavi%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Many%20traditional%20treatments%20have%20been%20recommended%20in%20the%20alternative%20system%20of%20medicine%20for%20the%20treatment%20of%20diabetes%20mellitus.%20The%20aim%20of%20this%20study%20was%20to%20assess%20oxidative%20stress%20and%20histological%20changes%20in%20the%20pancreas%20of%20alloxan-induced%20diabetic%20rats%20following%20Myristica%20fragrans%20seed%20%28nutmeg%29%20extract%20treatment.%5CnMATERIALS%20AND%20METHODS%3A%20Forty-eight%20male%20Wistar%20rats%20weighing%20200-250%20g%20were%20randomly%20divided%20into%20six%20groups%20of%208%20rats%20each%20-%20group%20I%2C%20non-diabetic%20rats%3B%20group%20II%2C%20diabetic%20rats%3B%20groups%20III%2C%20IV%20and%20V%2C%20diabetic%20rats%20given%20orally%20nutmeg%20extract%20at%20levels%20of%2050%2C%20100%20and%20200%20mg%5C%2Fkg%2C%20respectively%3B%20and%20group%20VI%2C%20diabetic%20rats%20given%20orally%20metformin%20%28100%20mg%5C%2Fkg%29.%20The%20experiment%20lasted%20for%2028%20days.%5CnRESULTS%3A%20Data%20showed%20that%20nutmeg%20extract%20%28100%20and%20200%20mg%5C%2Fkg%29%20significantly%20decreased%20the%20blood%20glucose%20levels%20and%20increased%20the%20levels%20of%20serum%20insulin%20in%20diabetic%20rats.%20Administration%20of%20nutmeg%20extract%20to%20diabetic%20rats%20reduced%20oxidative%20stress%20and%20improved%20the%20antioxidant%20activities%20in%20pancreatic%20tissue.%20Histopathologic%20results%20of%20treated%20groups%20revealed%20marked%20improvement%20in%20the%20morphology%20of%20the%20pancreas%20compared%20with%20the%20control%20diabetic%20group.%20In%20addition%2C%20number%20of%20pancreatic%20islets%20and%20per%20cent%20of%20%5Cu03b2-cells%20increased%20significantly%20in%20these%20groups%20in%20comparison%20with%20diabetic%20untreated%20group.%5CnCONCLUSIONS%3A%20These%20results%20suggest%20that%20nutmeg%20extract%20has%20potent%20antidiabetic%20and%20%5Cu03b2-cell%20protection%20activities%20in%20alloxan%20induced%20diabetic%20rats%2C%20possibly%20via%20its%20antioxidant%20properties.%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.5603%5C%2FFM.a2019.0052%22%2C%22ISSN%22%3A%221644-3284%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22U8LU2X8Y%22%5D%2C%22dateModified%22%3A%222020-08-29T02%3A12%3A06Z%22%7D%7D%2C%7B%22key%22%3A%22NQJ5QDUC%22%2C%22library%22%3A%7B%22id%22%3A6784680%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Dhingra%20and%20Sharma%22%2C%22parsedDate%22%3A%222006%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BDhingra%2C%20D.%2C%20%26amp%3B%20Sharma%2C%20A.%20%282006%29.%20Antidepressant-like%20activity%20of%20n-hexane%20extract%20of%20nutmeg%20%28Myristica%20fragrans%29%20seeds%20in%20mice.%20%26lt%3Bi%26gt%3BJournal%20of%20Medicinal%20Food%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B9%26lt%3B%5C%2Fi%26gt%3B%281%29%2C%2084%26%23x2013%3B89.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1089%5C%2Fjmf.2006.9.84%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1089%5C%2Fjmf.2006.9.84%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Antidepressant-like%20activity%20of%20n-hexane%20extract%20of%20nutmeg%20%28Myristica%20fragrans%29%20seeds%20in%20mice%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dinesh%22%2C%22lastName%22%3A%22Dhingra%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amandeep%22%2C%22lastName%22%3A%22Sharma%22%7D%5D%2C%22abstractNote%22%3A%22The%20present%20study%20was%20undertaken%20to%20investigate%20the%20effect%20of%20an%20n-hexane%20extract%20of%20Myristica%20fragrans%20seeds%20on%20depression%20in%20mice%20by%20using%20the%20forced%20swim%20test%20%28FST%29%20and%20the%20tail%20suspension%20test%20%28TST%29.%20M.%20fragrans%20extract%20%285%2C%2010%2C%20and%2020%20mg%5C%2Fkg%29%20was%20administered%20orally%20for%203%20successive%20days%20to%20different%20groups%20of%20Swiss%20male%20young%20albino%20mice.%20M.%20fragrans%20extract%20significantly%20decreased%20immobility%20periods%20of%20mice%20in%20both%20the%20FST%20and%20the%20TST.%20The%2010%20mg%5C%2Fkg%20dose%20was%20found%20to%20be%20most%20potent%2C%20as%20indicated%20by%20the%20greatest%20decrease%20in%20the%20immobility%20period%20compared%20with%20the%20control.%20Furthermore%2C%20this%20dose%20of%20the%20extract%20was%20found%20to%20have%20comparable%20potency%20to%20imipramine%20%2815%20mg%5C%2Fkg%20i.p.%29%20and%20fluoxetine%20%2820%20mg%5C%2Fkg%20i.p.%29.%20The%20extract%20did%20not%20have%20a%20significant%20effect%20on%20locomotor%20activity%20of%20mice.%20Prazosin%20%2862.5%20microg%5C%2Fkg%20i.p.%3B%20an%20alpha%20%281%29-adrenoceptor%20antagonist%29%2C%20sulpiride%20%2850%20mg%5C%2Fkg%20i.p.%3B%20a%20selective%20D%282%29%20receptor%20antagonist%29%2C%20and%20p-chlorophenylalanine%20%28100%20mg%5C%2Fkg%20i.p.%3B%20an%20inhibitor%20of%20serotonin%20synthesis%29%20significantly%20attenuated%20the%20M.%20fragrans%20extract-induced%20antidepressant-like%20effect%20in%20the%20TST.%20Thus%2C%20extract%20of%20M.%20fragrans%20elicited%20a%20significant%20antidepressant-like%20effect%20in%20mice%2C%20when%20assessed%20in%20both%20the%20TST%20and%20the%20FST.%20The%20antidepressant-like%20effect%20of%20the%20extract%20seems%20to%20be%20mediated%20by%20interaction%20with%20the%20adrenergic%2C%20dopaminergic%2C%20and%20serotonergic%20systems.%22%2C%22date%22%3A%222006%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1089%5C%2Fjmf.2006.9.84%22%2C%22ISSN%22%3A%221096-620X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22U8LU2X8Y%22%5D%2C%22dateModified%22%3A%222020-08-29T02%3A12%3A03Z%22%7D%7D%2C%7B%22key%22%3A%22V7VS9GII%22%2C%22library%22%3A%7B%22id%22%3A6784680%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Onyenibe%20et%20al.%22%2C%22parsedDate%22%3A%222015-06%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BOnyenibe%2C%20N.%20S.%2C%20Fowokemi%2C%20K.%20T.%2C%20%26amp%3B%20Emmanuel%2C%20O.%20B.%20%282015%29.%20African%20Nutmeg%20%28Monodora%20Myristica%29%20Lowers%20Cholesterol%20and%20Modulates%20Lipid%20Peroxidation%20in%20Experimentally%20Induced%20Hypercholesterolemic%20Male%20Wistar%20Rats.%20%26lt%3Bi%26gt%3BInternational%20Journal%20of%20Biomedical%20Science%26%23x202F%3B%3A%20IJBS%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B11%26lt%3B%5C%2Fi%26gt%3B%282%29%2C%2086%26%23x2013%3B92.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC4502738%5C%2F%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC4502738%5C%2F%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22African%20Nutmeg%20%28Monodora%20Myristica%29%20Lowers%20Cholesterol%20and%20Modulates%20Lipid%20Peroxidation%20in%20Experimentally%20Induced%20Hypercholesterolemic%20Male%20Wistar%20Rats%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nwozo%20Sarah%22%2C%22lastName%22%3A%22Onyenibe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kasumu%20Titilayo%22%2C%22lastName%22%3A%22Fowokemi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oyinloye%20Babatunji%22%2C%22lastName%22%3A%22Emmanuel%22%7D%5D%2C%22abstractNote%22%3A%22To%20evaluate%20the%20cholesterol%20lowering%20potential%20and%20protective%20ability%20of%20aqueous%20extract%20of%20Monodora%20myristica%20experimental%20hypercholesterolemic%20rats%2C%20a%20short-term%20study%20was%20conducted.%20Hypercholesterolemia%20was%20induced%20by%20administering%20cholesterol%20orally%20at%20a%20dose%20of%2040%20mg%5C%2Fkg%5C%2F0.3%20ml.%20Plant%20extracts%20100%20or%20200%20mg%5C%2Fkg%20body%20weight%20and%20Questran%200.26%20g%5C%2Fkg%20were%20administered%20five%20times%20a%20week%20for%20eight%20weeks%20for%20amelioration.%20Hypolipidemic%20effects%20were%20evaluated%20by%20measuring%20total%20cholesterol%20%28TC%29%2C%20low-density%20lipoprotein%20cholesterol%20%28LDL-C%29%2C%20high-density%20lipoprotein%20cholesterol%20%28HDL-C%29%20and%20triglycerides%20%28TG%29%20in%20the%20serum%2C%20while%20the%20protective%20ability%20was%20measured%20by%20the%20extent%20of%20lipid%20peroxidation%20%28LPO%29%20as%20well%20as%20enzymatic%20and%20non-enzymatic%20antioxidants%20levels%20in%20post%20mitochondrial%20fractions%20%28PMF%29%20of%20the%20hepatic%20and%20cardiac%20homogenates.%20Serum%20aminotransferases%20activities%20were%20also%20monitored.%20Results%20obtained%20shows%20that%20treatment%20with%20M.%20myristica%20elicited%20a%20significant%20reduction%20in%20serum%20TC%2C%20TG%20and%20LDL-C%20levels%20while%20there%20was%20concomitant%20increase%20in%20HDL-C%20of%20hypercholesterolemic%20rats.%20Elevations%20in%20serum%20aminotransferases%20activities%20and%20LPO%20level%20were%20reversed%20and%20a%20significant%20amelioration%20was%20noticed%20in%20enzymatic%20and%20non-enzymatic%20antioxidants%20status%20in%20the%20liver%20and%20heart%20of%20hypercholesterolemic%20rats.%20This%20study%20suggests%20that%20M.%20myristica%20possess%20cholesterol%20lowering%20potentials%20and%20protective%20ability%20in%20experimental%20hypercholesterolemia%20rat%20model.%22%2C%22date%22%3A%222015-6%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%22%22%2C%22ISSN%22%3A%221550-9702%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC4502738%5C%2F%22%2C%22collections%22%3A%5B%22U8LU2X8Y%22%5D%2C%22dateModified%22%3A%222020-08-29T02%3A12%3A01Z%22%7D%7D%2C%7B%22key%22%3A%22RZ7RYJKS%22%2C%22library%22%3A%7B%22id%22%3A6784680%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Tajuddin%20et%20al.%22%2C%22parsedDate%22%3A%222003-10-20%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BTajuddin%2C%20%20null%2C%20Ahmad%2C%20S.%2C%20Latif%2C%20A.%2C%20%26amp%3B%20Qasmi%2C%20I.%20A.%20%282003%29.%20Aphrodisiac%20activity%20of%2050%25%20ethanolic%20extracts%20of%20Myristica%20fragrans%20Houtt.%20%28nutmeg%29%20and%20Syzygium%20aromaticum%20%28L%29%20Merr.%20%26amp%3B%20Perry.%20%28clove%29%20in%20male%20mice%3A%20a%20comparative%20study.%20%26lt%3Bi%26gt%3BBMC%20Complementary%20and%20Alternative%20Medicine%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B3%26lt%3B%5C%2Fi%26gt%3B%2C%206.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2F1472-6882-3-6%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2F1472-6882-3-6%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Aphrodisiac%20activity%20of%2050%25%20ethanolic%20extracts%20of%20Myristica%20fragrans%20Houtt.%20%28nutmeg%29%20and%20Syzygium%20aromaticum%20%28L%29%20Merr.%20%26%20Perry.%20%28clove%29%20in%20male%20mice%3A%20a%20comparative%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22null%22%2C%22lastName%22%3A%22Tajuddin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shamshad%22%2C%22lastName%22%3A%22Ahmad%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abdul%22%2C%22lastName%22%3A%22Latif%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Iqbal%20Ahmad%22%2C%22lastName%22%3A%22Qasmi%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Spices%20are%20considered%20as%20sexual%20invigorators%20in%20the%20Unani%20System%20of%20Medicine.%20In%20order%20to%20explore%20the%20sexual%20function%20improving%20effect%20of%20Myristica%20fragrans%20Houtt.%20%28nutmeg%29%20and%20Syzygium%20aromaticum%20%28L%29%20Merr.%20%26amp%3B%20Perry.%20%28clove%29%20an%20experimental%20study%20was%20conducted%20in%20normal%20male%20mice.%5CnMETHODS%3A%20The%20extracts%20%2850%25%20ethanolic%29%20of%20nutmeg%20and%20clove%20were%20administered%20%28500%20mg%5C%2Fkg%3B%20p.o.%29%20to%20different%20groups%20of%20male%20Swiss%20mice.%20Mounting%20behaviour%2C%20mating%20performance%2C%20and%20general%20short%20term%20toxicity%20of%20the%20test%20drugs%20were%20determined%20and%20compared%20with%20the%20standard%20drug%20Penegra%20%28Sildenafil%20citrate%29.%5CnRESULTS%3A%20The%20extracts%20of%20the%20nutmeg%20and%20clove%20were%20found%20to%20stimulate%20the%20mounting%20behaviour%20of%20male%20mice%2C%20and%20also%20to%20significantly%20increase%20their%20mating%20performance.%20The%20drugs%20were%20devoid%20of%20any%20conspicuous%20general%20short%20term%20toxicity.%5CnCONCLUSION%3A%20The%20extracts%20%2850%25%20ethanolic%29%20of%20nutmeg%20and%20clove%20enhanced%20the%20sexual%20behaviour%20of%20male%20mice.%22%2C%22date%22%3A%22Oct%2020%2C%202003%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1186%5C%2F1472-6882-3-6%22%2C%22ISSN%22%3A%221472-6882%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22U8LU2X8Y%22%5D%2C%22dateModified%22%3A%222020-08-29T02%3A11%3A51Z%22%7D%7D%2C%7B%22key%22%3A%229UHHBGGQ%22%2C%22library%22%3A%7B%22id%22%3A6784680%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Tajuddin%20et%20al.%22%2C%22parsedDate%22%3A%222005-07-20%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BTajuddin%2C%20Ahmad%2C%20S.%2C%20Latif%2C%20A.%2C%20Qasmi%2C%20I.%20A.%2C%20%26amp%3B%20Amin%2C%20K.%20M.%20Y.%20%282005%29.%20An%20experimental%20study%20of%20sexual%20function%20improving%20effect%20of%20Myristica%20fragrans%20Houtt.%20%28nutmeg%29.%20%26lt%3Bi%26gt%3BBMC%20Complementary%20and%20Alternative%20Medicine%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B5%26lt%3B%5C%2Fi%26gt%3B%2C%2016.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2F1472-6882-5-16%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2F1472-6882-5-16%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22An%20experimental%20study%20of%20sexual%20function%20improving%20effect%20of%20Myristica%20fragrans%20Houtt.%20%28nutmeg%29%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22%22%2C%22lastName%22%3A%22Tajuddin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shamshad%22%2C%22lastName%22%3A%22Ahmad%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abdul%22%2C%22lastName%22%3A%22Latif%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Iqbal%20Ahmad%22%2C%22lastName%22%3A%22Qasmi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kunwar%20Mohammad%20Yusuf%22%2C%22lastName%22%3A%22Amin%22%7D%5D%2C%22abstractNote%22%3A%22Background%5CnMyristica%20fragrans%20Houtt.%20%28nutmeg%29%20has%20been%20mentioned%20in%20Unani%20medicine%20to%20be%20of%20value%20in%20the%20management%20of%20male%20sexual%20disorders.%20The%20present%20study%20was%20undertaken%20to%20evaluate%20the%20aphrodisiac%20effect%20of%2050%25%20ethanolic%20extract%20of%20nutmeg%20along%20with%20its%20likely%20adverse%20effects%20and%20acute%20toxicity%20using%20various%20animal%20models.%5Cn%5CnMethods%5CnThe%20suspension%20of%20the%20extract%20was%20administered%20%28100%2C%20250%20and%20500%20mg%5C%2Fkg%2C%20p.o.%29%20to%20different%20groups%20of%20male%20rats%20daily%20for%20seven%20days.%20The%20female%20rats%20involved%20in%20mating%20were%20made%20receptive%20by%20hormonal%20treatment.%20The%20general%20mating%20behaviour%2C%20libido%20and%20potency%20were%20studied%20and%20compared%20with%20the%20standard%20reference%20drug%20sildenafil%20citrate.%20Likely%20adverse%20effects%20and%20acute%20toxicity%20of%20the%20extract%20were%20also%20evaluated.%5Cn%5CnResults%5CnOral%20administration%20of%20the%20extract%20at%20the%20dose%20of%20500%20mg%5C%2Fkg%2C%20produced%20significant%20augmentation%20of%20sexual%20activity%20in%20male%20rats.%20It%20significantly%20increased%20the%20Mounting%20Frequency%2C%20Intromission%20Frequency%2C%20Intromission%20Latency%20and%20caused%20significant%20reduction%20in%20the%20Mounting%20Latency%20and%20Post%20Ejaculatory%20Interval.%20It%20also%20significantly%20increased%20Mounting%20Frequency%20with%20penile%20anaesthetisation%20as%20well%20as%20Erections%2C%20Quick%20Flips%2C%20Long%20Flips%20and%20the%20aggregate%20of%20penile%20reflexes%20with%20penile%20stimulation.%20The%20extract%20was%20also%20observed%20to%20be%20devoid%20of%20any%20adverse%20effects%20and%20acute%20toxicity.%5Cn%5CnConclusion%5CnThe%20resultant%20significant%20and%20sustained%20increase%20in%20the%20sexual%20activity%20of%20normal%20male%20rats%20without%20any%20conspicuous%20adverse%20effects%20indicates%20that%20the%2050%25%20ethanolic%20extract%20of%20nutmeg%20possesses%20aphrodisiac%20activity%2C%20increasing%20both%20libido%20and%20potency%2C%20which%20might%20be%20attributed%20to%20its%20nervous%20stimulating%20property.%20The%20present%20study%20thus%20provides%20a%20scientific%20rationale%20for%20the%20traditional%20use%20of%20nutmeg%20in%20the%20management%20of%20male%20sexual%20disorders.%22%2C%22date%22%3A%222005-7-20%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2F1472-6882-5-16%22%2C%22ISSN%22%3A%221472-6882%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC1187868%5C%2F%22%2C%22collections%22%3A%5B%22U8LU2X8Y%22%5D%2C%22dateModified%22%3A%222020-08-29T02%3A11%3A39Z%22%7D%7D%2C%7B%22key%22%3A%22WTCGI6SE%22%2C%22library%22%3A%7B%22id%22%3A6784680%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zhang%20et%20al.%22%2C%22parsedDate%22%3A%222016-04-26%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BZhang%2C%20W.%20K.%2C%20Tao%2C%20S.-S.%2C%20Li%2C%20T.-T.%2C%20Li%2C%20Y.-S.%2C%20Li%2C%20X.-J.%2C%20Tang%2C%20H.-B.%2C%20Cong%2C%20R.-H.%2C%20Ma%2C%20F.-L.%2C%20%26amp%3B%20Wan%2C%20C.-J.%20%282016%29.%20Nutmeg%20oil%20alleviates%20chronic%20inflammatory%20pain%20through%20inhibition%20of%20COX-2%20expression%20and%20substance%20P%20release%20in%20vivo.%20%26lt%3Bi%26gt%3BFood%20%26amp%3B%20Nutrition%20Research%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B60%26lt%3B%5C%2Fi%26gt%3B.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3402%5C%2Ffnr.v60.30849%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3402%5C%2Ffnr.v60.30849%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Nutmeg%20oil%20alleviates%20chronic%20inflammatory%20pain%20through%20inhibition%20of%20COX-2%20expression%20and%20substance%20P%20release%20in%20vivo%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wei%20Kevin%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shan-Shan%22%2C%22lastName%22%3A%22Tao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ting-Ting%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yu-Sang%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiao-Jun%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22He-Bin%22%2C%22lastName%22%3A%22Tang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ren-Huai%22%2C%22lastName%22%3A%22Cong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fang-Li%22%2C%22lastName%22%3A%22Ma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chu-Jun%22%2C%22lastName%22%3A%22Wan%22%7D%5D%2C%22abstractNote%22%3A%22Background%5CnChronic%20pain%2C%20or%20sometimes%20referred%20to%20as%20persistent%20pain%2C%20reduces%20the%20life%20quality%20of%20patients%20who%20are%20suffering%20from%20chronic%20diseases%20such%20as%20inflammatory%20diseases%2C%20cancer%20and%20diabetes.%20Hence%2C%20herbal%20medicines%20draw%20many%20attentions%20and%20have%20been%20shown%20effective%20in%20the%20treatment%20or%20relief%20of%20pain.%5Cn%5CnMethods%20and%20Results%5CnHere%20in%20this%20study%2C%20we%20used%20the%20CFA-injected%20rats%20as%20a%20sustainable%20pain%20model%20to%20test%20the%20anti-inflammatory%20and%20analgesic%20effect%20of%20nutmeg%20oil%2C%20a%20spice%20flavor%20additive%20to%20beverages%20and%20baked%20goods%20produced%20from%20the%20seed%20of%20Myristica%20fragrans%20tree.%5Cn%5CnConclusions%5CnWe%20have%20demonstrated%20that%20nutmeg%20oil%20could%20potentially%20alleviate%20the%20CFA-injection%20induced%20joint%20swelling%2C%20mechanical%20allodynia%20and%20heat%20hyperanalgesia%20of%20rats%20through%20inhibition%20of%20COX-2%20expression%20and%20blood%20substance%20P%20level%2C%20which%20made%20it%20possible%20for%20nutmeg%20oil%20to%20be%20a%20potential%20chronic%20pain%20reliever.%22%2C%22date%22%3A%222016-4-26%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.3402%5C%2Ffnr.v60.30849%22%2C%22ISSN%22%3A%221654-661X%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC4848392%5C%2F%22%2C%22collections%22%3A%5B%22U8LU2X8Y%22%5D%2C%22dateModified%22%3A%222020-08-29T02%3A11%3A36Z%22%7D%7D%2C%7B%22key%22%3A%22I65HTAAV%22%2C%22library%22%3A%7B%22id%22%3A6784680%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Morikawa%20et%20al.%22%2C%22parsedDate%22%3A%222018-03%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMorikawa%2C%20T.%2C%20Hachiman%2C%20I.%2C%20Ninomiya%2C%20K.%2C%20Hata%2C%20H.%2C%20Sugawara%2C%20K.%2C%20Muraoka%2C%20O.%2C%20%26amp%3B%20Matsuda%2C%20H.%20%282018%29.%20Degranulation%20inhibitors%20from%20the%20arils%20of%20Myristica%20fragrans%20in%20antigen-stimulated%20rat%20basophilic%20leukemia%20cells.%20%26lt%3Bi%26gt%3BJournal%20of%20Natural%20Medicines%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B72%26lt%3B%5C%2Fi%26gt%3B%282%29%2C%20464%26%23x2013%3B473.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs11418-017-1170-x%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs11418-017-1170-x%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Degranulation%20inhibitors%20from%20the%20arils%20of%20Myristica%20fragrans%20in%20antigen-stimulated%20rat%20basophilic%20leukemia%20cells%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Toshio%22%2C%22lastName%22%3A%22Morikawa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ikuko%22%2C%22lastName%22%3A%22Hachiman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kiyofumi%22%2C%22lastName%22%3A%22Ninomiya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hiroki%22%2C%22lastName%22%3A%22Hata%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kaoru%22%2C%22lastName%22%3A%22Sugawara%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Osamu%22%2C%22lastName%22%3A%22Muraoka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hisashi%22%2C%22lastName%22%3A%22Matsuda%22%7D%5D%2C%22abstractNote%22%3A%22A%20methanol%20extract%20of%20mace%2C%20the%20aril%20of%20Myristica%20fragrans%20%28Myristicaceae%29%2C%20was%20found%20to%20inhibit%20the%20release%20of%20%5Cu03b2-hexosaminidase%2C%20a%20marker%20of%20antigen-IgE-stimulated%20degranulation%20in%20rat%20basophilic%20leukemia%20cells%20%28RBL-2H3%2C%20IC50%5Cu00a0%3D%5Cu00a045.7%5Cu00a0%5Cu03bcg%5C%2Fml%29.%20From%20the%20extract%2C%20three%20new%208-O-4%26%23039%3B%20type%20neolignans%2C%20maceneolignans%20I-K%20%281-3%29%2C%20were%20isolated%2C%20and%20the%20stereostructures%20of%201-3%20were%20elucidated%20based%20on%20spectroscopic%20and%20chemical%20evidence.%20Among%20the%20isolates%2C%20maceneolignans%20A%20%285%29%2C%20D%20%286%29%2C%20and%20H%20%288%29%2C%20%28-%29-%288R%29-%5Cu22068%26%23039%3B-4-hydroxy-3%2C3%26%23039%3B%2C5%26%23039%3B-trimethoxy-8-O-4%26%23039%3B-neolignan%20%2813%29%2C%20%28-%29-%288R%29-%5Cu22068%26%23039%3B-3%2C4%2C5%2C3%26%23039%3B%2C5%26%23039%3B-pentamethoxy-8-O-4%26%23039%3B-neolignan%20%2814%29%2C%20%28-%29-erythro-%287R%2C8S%29-%5Cu22068%26%23039%3B-7-acetoxy-3%2C4-methylenedioxy-3%26%23039%3B%2C5%26%23039%3B-dimethoxy-8-O-4%26%23039%3B-neolignan%20%2817%29%2C%20%28%2B%29-licarin%20A%20%2820%29%2C%20nectandrin%20B%20%2824%29%2C%20verrucosin%20%2825%29%2C%20and%20malabaricone%20C%20%2829%29%20were%20investigated%20as%20possible%20degranulation%20inhibitors%20%28IC50%5Cu00a0%3D%5Cu00a020.7-63.7%5Cu00a0%5Cu03bcM%29.%20These%20inhibitory%20activities%20were%20more%20potent%20than%20those%20of%20the%20antiallergic%20agents%20tranilast%20%28282%5Cu00a0%5Cu03bcM%29%20and%20ketotifen%20fumalate%20%28158%5Cu00a0%5Cu03bcM%29.%20Compounds%205%2C%2025%2C%20and%2029%20also%20inhibited%20antigen-stimulated%20tumor%20necrosis%20factor-%5Cu03b1%20production%20%28IC50%5Cu00a0%3D%5Cu00a039.5-51.2%5Cu00a0%5Cu03bcM%29%2C%20an%20important%20process%20in%20the%20late%20phase%20of%20type%20I%20allergic%20reactions.%22%2C%22date%22%3A%22Mar%202018%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1007%5C%2Fs11418-017-1170-x%22%2C%22ISSN%22%3A%221861-0293%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22U8LU2X8Y%22%5D%2C%22dateModified%22%3A%222020-08-29T02%3A09%3A48Z%22%7D%7D%2C%7B%22key%22%3A%229AVJYFDJ%22%2C%22library%22%3A%7B%22id%22%3A6784680%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kirschmann%2C%20J.%2C%20%26%20Inc.%22%2C%22parsedDate%22%3A%222006%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BKirschmann%2C%20J.%2C%20%26amp%3B%20Inc.%20%282006%29.%20%26lt%3Bi%26gt%3BNutrition%20Almanac%26lt%3B%5C%2Fi%26gt%3B%20%286th%20ed.%29.%20McGraw%20Hill%20Publishing.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22book%22%2C%22title%22%3A%22Nutrition%20Almanac%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22%22%2C%22lastName%22%3A%22Kirschmann%2C%20J.%2C%20%26%20Inc.%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222006%22%2C%22language%22%3A%22%22%2C%22ISBN%22%3A%22%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22U8LU2X8Y%22%5D%2C%22dateModified%22%3A%222020-08-10T09%3A50%3A47Z%22%7D%7D%5D%7D
Brandi Marcene. (2019, September 24). 13 Amazing Health Benefits of Nutmeg. Natural Food Series. https://www.naturalfoodseries.com/13-health-benefits-nutmeg/
Stein, U., Greyer, H., & Hentschel, H. (2001). Nutmeg (myristicin) poisoning--report on a fatal case and a series of cases recorded by a poison information centre. Forensic Science International, 118(1), 87–90. https://doi.org/10.1016/s0379-0738(00)00369-8
Pashapoor, A., Mashhadyrafie, S., & Mortazavi, P. (2020). Ameliorative effect of Myristica fragrans (nutmeg) extract on oxidative status and histology of pancreas in alloxan induced diabetic rats. Folia Morphologica, 79(1), 113–119. https://doi.org/10.5603/FM.a2019.0052
Dhingra, D., & Sharma, A. (2006). Antidepressant-like activity of n-hexane extract of nutmeg (Myristica fragrans) seeds in mice. Journal of Medicinal Food, 9(1), 84–89. https://doi.org/10.1089/jmf.2006.9.84
Onyenibe, N. S., Fowokemi, K. T., & Emmanuel, O. B. (2015). African Nutmeg (Monodora Myristica) Lowers Cholesterol and Modulates Lipid Peroxidation in Experimentally Induced Hypercholesterolemic Male Wistar Rats. International Journal of Biomedical Science : IJBS, 11(2), 86–92. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502738/
Tajuddin, null, Ahmad, S., Latif, A., & Qasmi, I. A. (2003). Aphrodisiac activity of 50% ethanolic extracts of Myristica fragrans Houtt. (nutmeg) and Syzygium aromaticum (L) Merr. & Perry. (clove) in male mice: a comparative study. BMC Complementary and Alternative Medicine, 3, 6. https://doi.org/10.1186/1472-6882-3-6
Tajuddin, Ahmad, S., Latif, A., Qasmi, I. A., & Amin, K. M. Y. (2005). An experimental study of sexual function improving effect of Myristica fragrans Houtt. (nutmeg). BMC Complementary and Alternative Medicine, 5, 16. https://doi.org/10.1186/1472-6882-5-16
Zhang, W. K., Tao, S.-S., Li, T.-T., Li, Y.-S., Li, X.-J., Tang, H.-B., Cong, R.-H., Ma, F.-L., & Wan, C.-J. (2016). Nutmeg oil alleviates chronic inflammatory pain through inhibition of COX-2 expression and substance P release in vivo. Food & Nutrition Research, 60. https://doi.org/10.3402/fnr.v60.30849
Morikawa, T., Hachiman, I., Ninomiya, K., Hata, H., Sugawara, K., Muraoka, O., & Matsuda, H. (2018). Degranulation inhibitors from the arils of Myristica fragrans in antigen-stimulated rat basophilic leukemia cells. Journal of Natural Medicines, 72(2), 464–473. https://doi.org/10.1007/s11418-017-1170-x
Kirschmann, J., & Inc. (2006). Nutrition Almanac (6th ed.). McGraw Hill Publishing.

Share this post